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Amination and Amidation

Robinson Brothers routinely conducts reductive amination reactions to produce a wide range of speciality amine products and intermediates.

Reaction of an aliphatic or aromatic aldehyde, typically benzaldehyde’s, with a wide variety of alkyl amines to form an intermediate imine, which is subsequently reduced by catalytic hydrogenation to yield the amine with the product being distilled to required specifications.

Typical reductive amination transformations:

Amination 1

The reductive amination process offers a number of advantages over other preparative methods, amines thus produced typically having very low levels of the known process related impurities, particularly the absence of chlorides, providing both a good 'as produced' colour aspect and generally having a good shelf-life on storage under appropriate conditions.

Our further capabilities include the ability to handle in semi-bulk quantities anhydrous Ammonia and anhydrous Alkylamines e.g Methylamine. These reactants can be fed to reactors equipped with evaporator equipment allowing these reactants to be used in the gaseous phase, thus providing for various amidation chemistries, to yield amides and lower alkyl amides from e.g. carboxylic acids, acid chlorides and malonates.

Typical amidation transformations:

Amidation 2